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KMID : 0388220130200050310
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Journal of the Korean Rheumatism Association
2013 Volume.20 No. 5 p.310 ~ p.313
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A Case of Polyarthritis Associated with Reactivation of Chronic Hepatitis B Virus Infection
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Kang Dong-Hoon
Seo Young-Il
Kim Rul-Bin
Kim Ho-Joong
Lim Soo-Young
Han Ji-Suk
Song Su-Hee
Lim Soo-Kyung
Kim Hyun-Ah
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Abstract
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Hepatitis viruses (hepatitis B virus (HBV) and hepatitis C virus) have been associated with development of in-flammatory arthritis. Approximately 400 million people worldwide have chronic HBV infection. HBV infection is the one of the most common causes of liver disease, and the prevalence of HBV infection in Korea is almost 6%. Arthritis in patients with HBV can be encountered in two settings: as a rheumatoid arthritis (RA)-like, acute, self-limited polyarthritis during the pre-symptomatic phase of acute hepatitis B, or, more rarely, as arthritis oc-curring in the context of HBV-associated polyarteritis no-dosa (PAN). In both cases, the pathogenesis of arthritis is attributed to the deposition of immune complexes contain-ing viral antigens (HBsAg or HBeAg) and their respective antibodies (anti-HBs and anti-HBe) in synovial tissues. Here we report on a case of polyarthritis associated with reactivation of chronic hepatitis B virus infection with a review of the literature.
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KEYWORD
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Chronic hepatitis B , Immune complex , Polyar-thritis
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